Health & Environmental Research Online (HERO)


Print Feedback Export to File
8716399 
Journal Article 
Three/Four/Five-Component Diastereoselective Cyclization of Fischer Carbene Complexes, Lithium Enolates, and Allylmagnesium Bromide 
Barluenga, J; Pérez-Sánchez, I; Rubio, E; Flórez, J 
2003 
Yes 
Angewandte Chemie (International Edition)
ISSN: 1433-7851
EISSN: 1521-3773 
42 
47 
5860-5863 
English 
From three simple starting materials, the diastereoselective synthesis of pentasubstituted cyclopentanols or tetrasubstituted cyclohexane-1,4-diols can be controlled by the appropriate choice of lithium enolate (see scheme). The overall one-pot transformation leads to the formation of up to five new C-C bonds and up to four contiguous stereogenic centers. 
Carbenes; Chromium; Cyclization; Enolates multicomponent reactions