Matsumoto, M; Iso, T; Igarashi, T; Tanabe, S; Inoue, K; Hirose, A
As stipulated by the Chemical Substances Control Law, information on the hazards to human health associated with different chemical substances is collected by the Japanese Ministry of Health, Labour and Welfare. For this study, we reviewed all the information collected, including data on acute toxicity, repeated-dose toxicity, genotoxicity, and reproduction/developmental toxicity for chemical substances and assessed the hazards to human health associated with these chemicals. To clarify and evaluate the validity of each study, we created a dossier(composed of a collection of study data with a detailed summary of the methods, results, and conclusions for each study), using the International Uniform Chemical Information Database(IUCLID). In this fourth annual report, we present the summary hazard information related to potential effects on human health of the following five chemical substances: poly(oxy-1, 2-ethanediyl), alpha, alpha’-[(1-methylethylidene)di-4, 1-phenylene]bis [omega-hydroxy-(CAS: 32492-61-8), 2-chlorobenzoyl chloride(CAS: 609-65-4), 1, 1, 2, 2, 3, 3, 4, 4, 5, 6-decafluoro-5, 6-bis(trifluoromethyl)cyclohexane(CAS: 306-98-9), tetraphenyltin(IV)(CAS: 595-90-4), and 1, 3, 5-tri-tert-butylbenzene(CAS: 1460-02-2). The IUCLID dossiers created for these five chemical substances have been made available through the Japan Existing Chemical Data Base. Additional information on the hazards to human health of existing chemical substances will be provided using the same methodology and website when such becomes available. 2018, National Institute of Health Sciences. All rights reserved.