US EPA

8719919 

Journal Article 

Microencapsulation for preparing sustained release drugs 

Shashikala, P; Lavanya, A; Bhagavanth Rao, M 

2012 

1 

International Journal of Pharmacy and Pharmaceutical Sciences
ISSN: 2656-0097
EISSN: 0975-1491 

4 

SUPPL.1 

69-72 

English 

The work comprises of formulation and evaluation of microencapsulated sustained release Isoxsuprine Hydrochloride tablets using different proportions of Ethylcellulose, Polyethylene glycol 6000 and Polyethylene glycol 4000 as the coat material. Phase separation technique was used with Cyclohaxane as the solvent. The prepared granules were found to be free flowing and spherical in shape. X-Ray diffractometer was used to determine the size of the granules and the thickness of the coating. Tablets were prepared from stable granules. Parameters such as uniformity in thickness, friability, weight variation, hardness and the drug content of the tablets were evaluated. A six-stage dissolution test apparatus with phosphate buffer solution of 7.4P H was used to study the drug release pattern. The First Order Plot, Higuchi plot and the Koresmeyer et al plot were drawn. It was observed that the prepared formulation followed the Higuchi plot. The mechanism for drug release has been suggested as Diffusion. 

Ethyl cellulose; Isoxsuprine hydrochloride; Polyethylene glycol 4000; Polyethylene glycol 6000; Temperature change technique; X-ray diffractometer