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8721594 
Journal Article 
New simple UV spectrophotometric method for determination of Venlafaxine hydrochloride in Bulk and pharmaceutical dosage forms 
Lavanya, K; Sunitha, P; Anil Kumar, A; Venkata Ramana, K 
2013 
4 
1 
1-3 
English 
Venlafaxine is 1-[2-(dimethylamino)-1-(4-methoxyphenyl) ethyl] cyclohexan-1-ol, used as an antidepressant of the neither serotonin- nor epinephrine reuptake inhibitor (SNRI) class. It is prescribed for the treatment of clinical depression and anxiety disorders. In present work, a simple, sensitive, accurate and economical spectroscopic method has been developed for the estimation of Venlafaxine HCl in Bulk and its pharmaceutical dosage forms. An absorption maximum was found to be at 274 nm with the solvent system 0.1 N HCl. The drug follows Beer law in the range of 10-250 μg/ml with correlation coefficient of 0.9998. The percentage recovery of Venlafaxine HCl ranged from 99.97 to 100.05% in pharmaceutical dosage form. Results of the analysis were validated for accuracy, precision, LOD, LOQ and were found to be satisfactory. The proposed method is simple, rapid and suitable for the routine quality control analysis. 
Estimation; UV spectrophotometry; Validation; Venlafaxine