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8722115 
Journal Article 
Diastereo- and enantioselective organocatalytic direct conjugate addition of γ-Butenolide to chalcones 
Zhang, Y; Yu, C; Ji, Y; Wang, W 
2010 
Yes 
Chemistry - An Asian Journal
ISSN: 1861-4728
EISSN: 1861-471X 
5 
6 
1303-1306 
English 
20397189 
A diastereo- and enantioselective conjugate addition reaction of γ-butenolide with chalcones has been developed. Notably, unmodified γ-butenolide was directly employed as a nucleophile in the Michael addition reactions. This process was catalyzed by a previously reported cyclohexane diamine thiourea under mild reaction conditions to afford enantioenriched synthetically and biologically important substituted furanones. 2010 Wiley-VCH Verlag GmbH&Co. KGaA, Weinheim. 
Enones; Lactones; Michael addition organocatalysis; Thioureas