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8722348 
Journal Article 
Organocascade reactions of enones catalyzed by a chiral primary amine 
Wu, LY; Bencivenni, G; Mancinelli, M; Mazzanti, A; Bartoli, G; Melchiorre, P 
2009 
Yes 
Angewandte Chemie (International Edition)
ISSN: 1433-7851
EISSN: 1521-3773 
48 
39 
7196-7199 
English 
Primary amines do it differently: Acyclic α, β -unsaturated ketones are activated toward a characteristic stepwise double-Michael addition sequence by chiral primary amine catalysis, which offers a powerful alternative in the design of synthetically useful organocascade reactions (see scheme, EWG=electron-withdrawing group). This method complements the Diels-Alder reaction for the one-step synthesis of complex cyclohexane scaffolds with excellent optical purity. 2009 Wiley-VCH Verlag GmbH & Co. KCaA. 
Asymmetric catalysis; Domino reactions; Ketones; Organocatalysis; Quaternary stereocenters