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8722856 
Journal Article 
Preliminary studies on peripheral nerve regeneration using a new polyurethane conduit 
Yin, D; Wang, X; Yan, Y; Zhang, R 
2007 
Yes 
Journal of Bioactive and Compatible Polymers
ISSN: 0883-9115
EISSN: 1530-8030 
22 
2 
143-159 
English 
There is currently interest in the use of tube-shaped nerve guides to induce regeneration of severed peripheral nerve axons, to assist nerve growth in the correct directions and to provide protection for the regenerating nerves. In the present paper, preliminary studies on the degradation and biocompatibility of a new elastomeric polyurethane (PU), based on polycaprolactone, polyethylene glycol and 1,6-hexamethyl diisocyanate. The PU elastomer was evaluated in vivo for the repair of a 12-mm femoral nerve gap in rabbits. Histological and scanning electron microscope observations were carried out at three days and then 4, 8, 10 and 12 weeks postoperation. Electrophysiological recording was performed six months postoperation. Myelinated axon regeneration was observed from four weeks after implantation. Polymer degradation was observed over the duration of the study. The results suggest that PU channels can be used for the regeneration of peripheral nerves and are suitable for tissue engineering. 2007 SAGE Publications. 
Biocompatible; Biodegradation; Peripheral nerve regeneration; Polyurethane conduit