Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
8726695
Reference Type
Journal Article
Subtype
Review
Title
Pathogenesis and diagnosis of Shiga toxin-producing Escherichia coli infections
Author(s)
Paton, JC; Paton, AW
Year
1998
Is Peer Reviewed?
Yes
Journal
Clinical Microbiology Reviews
ISSN:
0893-8512
EISSN:
1098-6618
Volume
11
Issue
3
Page Numbers
450-479
Language
English
PMID
9665978
DOI
10.1128/CMR.11.3.450
Web of Science Id
WOS:000074714500005
URL
https://journals.asm.org/doi/10.1128/CMR.11.3.450
Exit
Abstract
Since their initial recognition 20 years ago, Shiga toxin-producing Escherichia coli (STEC) strains have emerged as an important cause of serious human gastrointestinal disease, which may result in life-threatening complications such as hemolytic-uremic syndrome. Food-borne outbreaks of STEC disease appear to be increasing and, when mass-produced and mass-distributed foods are concerned, can involve large numbers of people. Development of therapeutic and preventative strategies to combat STEC disease requires a thorough understanding of the mechanisms by which STEC organisms colonize the human intestinal tract and cause local and systemic pathological changes. While our knowledge remains incomplete, recent studies have improved our understanding of these processes, particularly the complex interaction between Shiga toxins and host cells, which is central to the pathogenesis of STEC disease. In addition, several putative accessory virulence factors have been identified and partly characterized. The capacity to limit the scale and severity of STEC disease is also dependent upon rapid and sensitive diagnostic procedures for analysis of human samples and suspect vehicles. The increased application of advanced molecular technologies in clinical laboratories has significantly improved our capacity to diagnose STEC infection early in the course of disease and to detect low levels of environmental contamination. This, in turn, has created a potential window of opportunity for future therapeutic intervention.
Tag
Other
•
Harmful Algal Blooms- Health Effects
Selected References March 2021
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity