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8728395 
Journal Article 
Review 
Chemoautotroph Cupriavidus necator as a potential game-changer for global warming and plastic waste problem: A review 
Sohn, YJ; Son, J; Jo, SY; Park, SY; Yoo, JI; Baritugo, KA; Na, JG; Choi, JI; Kim, HT; Joo, JC; Park, SJ 
2021 
Yes 
Bioresource Technology
ISSN: 0960-8524
EISSN: 1873-2976 
340 
125693 
English 
34365298 
Cupriavidus necator, a versatile microorganism found in both soil and water, can have both heterotrophic and lithoautotrophic metabolisms depending on environmental conditions. C. necator has been extensively examined for producing Polyhydroxyalkanoates (PHAs), the promising polyester alternatives to petroleum-based synthetic polymers because it has a superior ability for accumulating a considerable amount of PHAs from renewable resources. The development of metabolically engineered C. necator strains has led to their application for synthesizing biopolymers, biofuels and biochemicals such as ethanol, isobutanol and higher alcohols. Bio-based processes of recombinant C. necator have made much progress in production of these high-value products from biomass wastes, plastic wastes and even waste gases. In this review, we discuss the potential of C. necator as promising platform host strains that provide a great opportunity for developing a waste-based circular bioeconomy.