Health & Environmental Research Online (HERO)


Print Feedback Export to File
8780939 
Journal Article 
A review on the pharmacokinetics of paeoniflorin and its anti-inflammatory and immunomodulatory effects 
Zhou, Y; Cong, X; Zhang, H; Peng, C 
2020 
Yes 
Biomedicine & Pharmacotherapy
ISSN: 0753-3322
EISSN: 1950-6007 
Elsevier 
130 
Elsevier 
110505 
English 
32682112 
WOS:000582697900016 
Increasing pharmacological evidence supports that paeoniflorin, a water-soluble monoterpene glycoside isolated from Paeonia lactiflora Pall. (Shaoyao in Chinese), has a wide range of medicinal properties including anti-inflammatory, antioxidant, antithrombotic, anticonvulsive, analgesic, cardioprotective, neuroprotective, hepatoprotective, antidepressant-like, antitumoral, and immune-regulatory activities; as well as enhancing cognition and attenuating learning impairment. In addition to pharmacodynamic studies, information on pharmacokinetics is also significant for the further development and utilization of paeoniflorin. The present review focuses on the absorption, distribution, metabolism, and excretion of paeoniflorin, especially main pharmacological activities of paeoniflorin on inflammation and immune function. According to the findings obtained both in vitro and in vivo, a broad application prospect has been opened for paeoniflorin. However, further studies are needed to clarity the direct molecular mechanisms and key targets underlying the beneficial effects of paeoniflorin on inflammation and immunity. 
Paeoniflorin; Metabolism; Pharmacokinetics; Inflammation; Immunity; ALLERGIC CONTACT-DERMATITIS; HUMAN HEPATOCELLULAR-CARCINOMA; IMIQUIMOD-INDUCED PSORIASIS; BLOOD MONONUCLEAR-CELLS; FIBROBLAST-LIKE SYNOVIOCYTES; INDUCED OXIDATIVE STRESS; PAEONIA-LACTIFLORA; IMPROVES SURVIVAL; INHIBITS FUNCTION; DENDRITIC CELLS