US EPA

8803049 

Journal Article 

Effects of extract of licorice root on lipid peroxidation system in rats during long-term inhalation of small and large doses of uranium ore dust 

Jumasheva, RT; Toguzbaeva, KK; Dzhusupov, KO; Aidarov, ZA 

2017 

11 

4 

70-78 

English 

Aims. The article is aimed at to describe effects of the extract of licorice root on lipid peroxidation processes in rats inhaling small and large doses of uranium ore dust. Materials and methods. In healthy outbred male rats in different terms of inhalation of uranium ore dust (3-120 days) of different intensity (5, 10 and 50 MPC), the concentrations of malondialdehyde was assessed in their lung tissue and serum with and without oral administration of the LRE in 100 мг/kg of weight. Results. Effects of the uranium ore dust in doses of 5 and 10 MPC during adaptive reactions the rise of the contents malondialdehyde in the lungs was insignificant and reversible. The 3.4-3.5-fold increase of malondialdehyde content in lung tissue was marked at 120th day, with the pattern of destructive disorders and the appearance of pathological submicroscopic changes. At uranium ore dust inhalation in a dose of 50 MPCs, consistent growth of malondialdehyde in the lung tissues begins at 7th day when heavy destructive changes begin. The use of the licorice root in animals for a month after the entire period of inhalation of small doses of the uranium ore dust led to a slight decrease in malondialdehyde synthesis in pulmonary blood, but a sharp decrease in its release into blood. When exposed to the uranium ore dust at 50 MPCs, administering the licorice root had a significantly positive antioxidant and antitoxic effect, delaying lipids peroxidation in lung tissue and their release into blood. Conclusion. The oral administration of the licorice root to rats exposed to different doses of the uranium ore dust has positive, antioxidant and antitoxic effect, reducing the synthesis of lipid peroxidation products in lung tissue and their release into blood. © 2018, Yerevan State Medical University. All rights reserved. 

Licorice root extract; Lipid peroxidation processes; Lung tissue; Malondialdehyde; Uranium ore dust