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88393 
Journal Article 
delta-aminolevulinic acid dehydratase (ALAD) polymorphism and susceptibility of workers exposed to inorganic lead and its effects on neurobehavioral functions 
Chia, SE; Yap, E; Chia, KS 
2004 
1 
NeuroToxicology
ISSN: 0161-813X
EISSN: 1872-9711 
ELSEVIER SCIENCE BV 
AMSTERDAM 
25 
6 
1041-1047 
English 
15474621 
WOS:000224768000014 
We carried out a cross-sectional study on a group of male workers to determine the frequency of d-aminolevulinic acid dehydratase (ALAD) polymorphisms among Chinese, Malays and Indians workers who were exposed to low to medium levels of inorganic lead. Also, the association between ALAD1 and ALAD2 genotypes and neurobehavioral functions among these workers were investigated. A total of 120 male workers were studied. Blood and urine were collected for each worker to determine the ALAD genotypes, blood lead levels, ALAD, and urinary d-aminolevulinic acid (ALAU). ALAD1-1 was the predominant genotype for all three ethnic groups while ALAD2-2 was the rarest. The distribution of ALAD1-2 was higher among Malays (16.7%) and Indians (14.3%), compared to Chinese (3.6%). Selected tests from the World Health Organization Neurobehavioral Core Test Battery (WHO-NCTB) were used. Although workers in the ALAD1-1 and ALAD1-2/2-2 groups had comparable blood lead levels, the 106 workers with ALAD1-1 genotypes have significantly higher urinary ALA and significantly poorer neurobehavioral scores involving motor dexterity compared with those who have ALAD1-2/2-2 genotypes (13 workers). It is postulated that the ALAD2 allele may exert protective measures against the neurotoxic effects of lead. Further study involving a larger cohort of workers with the ALAD2 allele would be needed to confirm this hypothesis. 
ALAD polymorphism; Lead; Neurobehavioral functions; isoenzyme; lead; porphobilinogen synthase; porphobilinogen synthase 1; porphobilinogen synthase 2; unclassified drug; adult; article; blood sampling; Chinese; cognition; controlled study; disease predisposition; DNA polymorphism; ethnic group; genotype; human; Indian; Malaysia; male; motor performance; neurotoxicity; priority journal; urinalysis; worker; Adult; Chemical Industry; Cross-Sectional Studies; Gene Frequency; Humans; Lead; Male; Middle Aged; Occupational Exposure; Polymorphism, Genetic; Porphobilinogen Synthase; Psychomotor Disorders