A Simple Synthesis of Ethynyl Substituted Phenylacetonitrile Derivatives by Phase-Transfer Catalysis (PTC) | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

9088689

Reference Type

Journal Article

Title

A Simple Synthesis of Ethynyl Substituted Phenylacetonitrile Derivatives by Phase-Transfer Catalysis (PTC)

Author(s)

Jończyk, A; Kuliński, T; Czupryniak, M; Balcerzak, P

Year

1991

Is Peer Reviewed?

Journal

Synlett
ISSN: 0936-5214
EISSN: 1437-2096

Publisher

GEORG THIEME VERLAG

Location

STUTTGART

Volume

1991

Issue

Page Numbers

639-641

Language

English

DOI

10.1055/s-1991-22018

Web of Science Id

WOS:A1991GF09300013

Abstract

Reaction of phenylacetonitrile derivatives 1 with vinylidene chloride (2) in the presence of 50% aqueous sodium hydroxide and tetrabutylammonium hydrogen sulfate (TBAHS) as a catalyst (phase-Transfer catalysis, PTC) gives 2-substituted 2-ethynyl-2-phenylacetonitriles 3 in high yield. An addition-elimination route with the intermediacy of chloroacetylene is proposed. © 1991 Georg Thieme Verlag. All rights reserved.