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9089760 
Journal Article 
Review 
Zinc in traumatic brain injury: from neuroprotection to neurotoxicity 
Morris, DR; Levenson, CW; , 
2013 
Yes 
Current Opinion in Clinical Nutrition and Metabolic Care
ISSN: 1363-1950
EISSN: 1473-6519 
LIPPINCOTT WILLIAMS & WILKINS 
PHILADELPHIA 
708-711 
English 
23945221 
WOS:000326586800017 
In light of the recent recognition that even mild forms of traumatic brain injury (TBI) can lead to long-term cognitive and behavioral deficits, this review examines recent data on the neuroprotective and neurotoxic roles of zinc after brain injury.Data show that treatment using dietary and parenteral zinc supplementation can reduce TBI-associated depression and improve cognitive function, specifically spatial learning and memory. However, excessive release of free zinc, particularly in the hippocampus associated with acute injury, can lead to increases in protein ubiquitination and neuronal death.This work shows the need for future research to clarify the potentially contradictory roles of zinc in the hippocampus and define the clinical use of zinc as a treatment following brain injury in humans. This is particularly important given the finding that zinc may reduce TBI-associated depression, a common and difficult outcome to treat in all forms of TBI.