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HERO ID
9208119
Reference Type
Journal Article
Title
Synchronized network oscillations in rat tuberoinfundibular dopamine neurons: switch to tonic discharge by thyrotropin-releasing hormone
Author(s)
Lyons, DJ; Horjales-Araujo, E; Broberger, C; ,
Year
2010
Is Peer Reviewed?
1
Journal
Neuron
ISSN:
0896-6273
EISSN:
1097-4199
Publisher
CELL PRESS
Location
CAMBRIDGE
Page Numbers
217-229
Language
English
PMID
20152128
DOI
10.1016/j.neuron.2009.12.024
Web of Science Id
WOS:000274136100009
URL
https://linkinghub.elsevier.com/retrieve/pii/S0896627309010423
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Abstract
The pituitary hormone, prolactin, triggers lactation in nursing mothers. Under nonlactating conditions, prolactin secretion is suppressed by powerful inhibition from hypothalamic tuberoinfundibular dopamine (TIDA) neurons. Although firing pattern has been suggested as integral to neuroendocrine control, the electrical behavior of TIDA cells remains unknown. We demonstrate that rat TIDA neurons discharge rhythmically in a robust 0.05 Hz oscillation. The oscillation is phase locked between neurons, and while it persists during chemical synaptic transmission blockade, it is abolished by gap junction antagonists. Thyrotropin-releasing hormone (TRH) potently stimulates prolactin release, an effect assumed to take place in the pituitary. In TIDA cells, TRH caused a transition from phasic to tonic firing through combined pre- and postsynaptic effects. These findings suggest a model for prolactin regulation where a TIDA network switch from oscillations to sustained discharge converts dopamine from an antagonist at high concentrations to a functional agonist as dopamine output from the network decreases.
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