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HERO ID
9216089
Reference Type
Journal Article
Title
Developmental control of plasma leptin and adipose leptin messenger ribonucleic acid in the ovine fetus during late gestation: role of glucocorticoids and thyroid hormones
Author(s)
O'Connor, DM; Blache, D; Hoggard, N; Brookes, E; Wooding, FBP; Fowden, AL; Forhead, AJ; ,
Year
2007
Is Peer Reviewed?
Yes
Journal
Endocrinology
ISSN:
0013-7227
EISSN:
1945-7170
Publisher
ENDOCRINE SOC
Location
WASHINGTON
Page Numbers
3750-3757
Language
English
PMID
17495000
DOI
10.1210/en.2007-0310
Web of Science Id
WOS:000248086800025
URL
https://academic.oup.com/endo/article/148/8/3750/2502078
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Abstract
In developed countries, the increasing incidence of obesity is a serious health problem. Leptin exposure in the perinatal period affects long-term regulation of appetite and energy expenditure, but control of leptin production in utero is unclear. This study investigated perirenal adipose tissue (PAT) and placental leptin expression in ovine fetuses during late gestation and after manipulation of plasma glucocorticoid and thyroid hormone concentrations. Between 130 and 144 d of gestation (term at 145 +/- 2 d), plasma leptin and PAT leptin mRNA levels increased in association with increments in plasma cortisol and T(3). Fetal adrenalectomy prevented these developmental changes, and exposure of intact 130 d fetuses to glucocorticoids, by cortisol infusion or maternal dexamethasone treatment, caused premature elevations in plasma leptin and PAT leptin gene expression. Fetal thyroidectomy increased plasma leptin and PAT leptin mRNA abundance, whereas intravenous T(3) infusion to intact 130 d fetuses had no effect on circulating or PAT leptin. Leptin mRNA expression was low in the ovine placenta. Therefore, in the sheep fetus, PAT appears to be a primary source of leptin in the circulation, and leptin gene expression is regulated by both glucocorticoids and thyroid hormones. Developmental changes in circulating and PAT leptin may mediate the maturational effects of cortisol in utero and have long-term consequences for appetite regulation and the development of obesity.
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