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9304706 
Journal Article 
Evaluation of autoimmune thyroid disease in melasma 
Mogaddam, MR; Alamdari, MI; Maleki, N; Ardabili, NS; Abedkouhi, S; , 
2015 
Yes 
Journal of Cosmetic Dermatology
ISSN: 1473-2130
EISSN: 1473-2165 
WILEY 
HOBOKEN 
167-171 
English 
25810215 
WOS:000355219100012 
Melasma is one of the most frequently acquired hyperpigmentation disorders clinically characterized by symmetrical brown patches on sun-exposed areas. To date, few studies have been conducted about the relationship between thyroid autoimmun-ity and melasma. To evaluate the thyroid dysfunction and autoimmunity in nonpregnant women with melasma. A total of 70 women with melasma and 70 age-matched healthy women with no history of melasma were enrolled in the study. We studied the thyroid hormone profile in both groups. The statistical analysis was performed using SPSS software. Patients with melasma had 18.5% frequency of thyroid disorders, and 15.7% had positive anti-TPO, while subjects from the control group had a 4.3% frequency of thyroid abnormalities, and only 5.7% had positive anti-TPO. There was a significantly higher prevalence of thyroid dysfunction in women with melasma compared with control group (P = 0.008). This study suggests that there is a relationship between thyroid autoimmunity and melasma. However, to make recommendations on screening for thyroid disease in patients with melasma, future research of good methodological quality is needed.