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9305502 
Journal Article 
Inhibin B levels in hypothyroid males 
Donnelly, P; Tan, K; Winch, D; , 
2013 
1 
Thyroid
ISSN: 1050-7256
EISSN: 1557-9077 
MARY ANN LIEBERT, INC 
NEW ROCHELLE 
1379-1382 
English 
23692058 
WOS:000326578800005 
The primary role of inhibin B is the regulation of gametogenesis via negative feedback on the production of follicle stimulating hormone (FSH) by the pituitary.We studied 14 males with primary hypothyroidism due to various etiologies to determine if they exhibited hypogonadotrophic hypogonadism involving the reproductive segment of the gonadotrophic axis. Levels of inhibin B, FSH, luteinizing hormone, testosterone, free thyroxine, and thyrotropin were measured.The mean level of inhibin B in males with primary hypothyroidism was found to be approximately half that of normal males. The FSH level remained within the normal range and no reciprocal increase was observed as occurs in other conditions with reduced inhibin B.Our results indicate that primary hypothyroidism has a significant effect on inhibin B levels without reciprocal increase in FSH, which is consistent with a hypogonadotrophic hypogonadal state affecting the reproductive segment of the gonadotrophic axis.