Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
9312471
Reference Type
Journal Article
Title
Antidepressant-like effects of Albizzia julibrissin in mice: involvement of the 5-HT1A receptor system
Author(s)
Kim, JiH; Kim, SunY; Lee, SY; Jang, CGon; ,
Year
2007
Is Peer Reviewed?
1
Journal
Pharmacology, Biochemistry and Behavior
ISSN:
0091-3057
EISSN:
1873-5177
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Location
OXFORD
Page Numbers
41-47
Language
English
PMID
17477962
DOI
10.1016/j.pbb.2007.03.018
Web of Science Id
WOS:000247740300005
URL
https://linkinghub.elsevier.com/retrieve/pii/S0091305707001207
Exit
Abstract
The present study was undertaken to investigate the antidepressant-like effects of the methylene chloride fraction of Albizzia julibrissin (MCAJ) using a tail suspension test in mice. MCAJ was orally administered at 50, 100, or 200 mg/kg to mice, 1 h before the tail suspension test. Acute treatment with MCAJ at 200 mg/kg significantly reduced the immobility time compared with the control group, and thus showed an antidepressant-like effect. This effect was comparable to that of imipramine at 10 mg/kg. This antidepressant-like effect was reversed by treatment with WAY-100635 (a 5-HT1A receptor antagonist) or pindolol (a 5-HT1A/1B receptor antagonist). However, the antidepressant effect of MCAJ was not effected by treatment with GR55562 (a 5-HT1B receptor antagonist) or ketanserin (a 5-HT2A receptor antagonist). Therefore, our findings suggest that MCAJ exerts its antidepressant-like effect via the 5-HT1A receptor system.
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity