Synthesis and biological activity of some 4-amino-3-cinnoline carboxylic acid derivatives. Part 4: 2,4-Dioxo-1,2,3,4-tetrahydropyrimido[5,4-c]cinnolines | Health & Environmental Research Online (HERO)

Health & Environmental Research Online (HERO)

Print Feedback Export to File

This record has one attached file:

Citation
Tags

HERO ID

9313304

Reference Type

Journal Article

Title

Synthesis and biological activity of some 4-amino-3-cinnoline carboxylic acid derivatives. Part 4: 2,4-Dioxo-1,2,3,4-tetrahydropyrimido[5,4-c]cinnolines

Author(s)

Stanczak, A; Lewgowd, W; Pakulska, W; ,

Year

1998

Is Peer Reviewed?

Yes

Journal

Die Pharmazie
ISSN: 0031-7144

Publisher

GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH

Location

ESCHBORN

Page Numbers

156-161

Language

English

PMID

9547518

Web of Science Id

WOS:000072789800002

Abstract

A series of new 2,4-dioxo-1,2,3,4-tetrahydropyrimido[5,4-c]cinnolines and their 3-substituted derivatives were prepared. These compounds were obtained by cyclocondensation of the appropriate substituted 4-amino-3-cinnolinecarboxylic acid with urea or 4-amino-3-cinnolinecarboxamides with N,N'-carbonyldiimidazole (DCl), oxalyl chloride or diethyl carbonate. Most of these compounds showed a high sedative action in low doses.