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9428344 
Journal Article 
New ion selective electrode for potentiometric determination of gatifloxacin in pure form and pharmaceutical formulations 
Mandil, H; Sakur, AA; Nasser, B 
2013 
1 
International Journal of Pharmacy and Pharmaceutical Sciences
ISSN: 2656-0097
EISSN: 0975-1491 
5 
SUPPL. 2 
423-428 
English 
A new type of ion-selective electrode for the determination of gatifloxacin (GTFX) is presented. Ion selective coated wire sensors have been constructed from the incorporation of GTFX and tetraphenyl borate(TPB) with the ion-pairing agents (IP), plasticised polyvinyl chloride (PVC) and bis(2-ethylhexyl) phthalate (DOP) or dibutyl phthalate (DBP). The two sensors show nearly Nernestian response over the concentration range 1.0×10-5-1.0 ×10-2 mol L-1 at 25°C over the pH range 2-6 with slopes of 59.12±0.08mv and 51.50±0.14mV decade-1 for (GTFX-TPB-DBP) and (GTFX-TPB-DOP) coated wire sensors. The electrodes exhibit a fast dynamic response of 5.0 and 10 s for a period of 15 days for (GTFX-TPB -DBP) and (GTFX-TPB-DOP) coated wire sensors, respectively. The sensors exhibit good selectivity for GTFX with respect to some inorganic compounds. The sensor served as an end-point detector in ion-pair surfactant potentiometric titrations using TPB as titrant. The method is accurate and precise as indicated by the mean recoveries 99.00% with RSD less than 1.6% for (GTFX-TPB-DBP) or (GTFX-TPB-DOP) coated wire sensors. The proposed method was successfully applied for the determination of GTFX in pure form and its pharmaceutical formulations. 
Gatifloxacin; Ion-selective electrodes; Potentiometric membrane sensor; gati; gatifloxacin; phthalic acid bis (2 ethylhexyl) ester; phthalic acid dibutyl ester; polyvinylchloride; tequinine; tetraphenylboron; unclassified drug; article; calibration; drug determination; ion selective electrode; limit of detection; limit of quantitation; measurement accuracy; measurement precision; pH; potentiometry; robustness; sensor; validation study