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HERO ID
9429149
Reference Type
Journal Article
Title
Determination of phthalates in leachates from commonly used plastic pouches and in biological tissues of leachates exposed rats
Author(s)
Ojha, P; Ojha, CS; Sharma, VP
Year
2005
Is Peer Reviewed?
Chk
Journal
Indian Journal of Environmental Protection
ISSN:
0253-7141
Publisher
Kalpana Corporation
Volume
25
Issue
11
Page Numbers
1025-1028
Language
English
URL
https://www.scopus.com/inward/record.uri?eid=2-s2.0-33645512951&partnerID=40&md5=c4dfd52d3dc5ff6d707f370fe76b55ab
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Abstract
Phthalates are widely used as plasticizers to impart softness and flexibility to the finished plastic and constitute 40-60% of the polymer. In present study, attempts were made to estimate phthalates content in leachates from commonly used plastic (pouches) in simulating condition media, such as water and normal saline using high pressure liquid chromatography (HPLC). The phthalates measured were di-ethyl-hexyl phthalates (DEHP), di-butyl-phthalate (DBP) and di-methyl-phthalate (DMP). In order to assess the continuous leachability, if any, the procedure of exraction was repeated 3 times in identical conditions using same plastic and no significant leachability of any of the phthalate could be observed in 2nd, 3rd and 4th extractions revealing no leachability of phthalates on repeated extraction. In order to assess the accumulation of phthalates in experimental rats fed with leachates for a period of 90 day. The maximum accumulation was observed in liver of rats fed with leachates as compare to vehicle fed animals. Since phathalates are known hepatotoxic and also known to have estrogenic potential. The present study on leachability and accumulation in vital organ may be of relevance in correlating the toxic effect of plastic leachates. © 2005 - Kalpana Corporation.
Keywords
High pressure liquid chromatography (HPLC); Leachates; Plastics; Animalia
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