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9429523 
Journal Article 
Gas chromatographic determination of clopidogrel from tablet dosage forms 
Kamble, NS; Venkatachalam, A 
2005 
Yes 
Indian Journal of Pharmaceutical Sciences
ISSN: 0250-474X
EISSN: 1998-3743 
67 
1 
128-129 
English 
A gas chromatographic method was developed for the determination of clopidogrel in its tablet form. The method involves use of a DB-17 capillary column. Column is of 30 m length, 0.25 mm i.d. and 0.25 μ film thickness, and hydrogen as a carrier gas with the flow rate of 2.0 ml/min. Oven temperature was maintained at 250° for 8 min. Split type of injector and flame ionization detector was used.The retention time of clopidogrel and dioctyl phthalate (internal standard ) was 4.1 min and 3.2 min, respectively. Linearity for the clopidogrel was in the range of 0.5 to 5.0 mg/ml. Percentage recovery obtained was 99.89.The proposed method is accurate, precise and rapid for the estimation of clopidogrel.