Thyroid antibody positivity in the first trimester of pregnancy is associated with negative pregnancy outcomes | Health & Environmental Research Online (HERO)

HERO ID

9433268

Reference Type

Journal Article

Title

Thyroid antibody positivity in the first trimester of pregnancy is associated with negative pregnancy outcomes

Author(s)

Negro, R; Schwartz, A; Gismondi, R; Tinelli, A; Mangieri, T; Stagnaro-Green, A; ,

Year

2011

Is Peer Reviewed?

Yes

Journal

Journal of Clinical Endocrinology and Metabolism
ISSN: 0021-972X
EISSN: 1945-7197

Publisher

ENDOCRINE SOC

Location

CHEVY CHASE

Page Numbers

E920-E924

Language

English

PMID

21411559

DOI

10.1210/jc.2011-0026

Web of Science Id

WOS:000290810200007

URL

https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2011-0026
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Abstract

Thyroid antibody positivity during pregnancy has been associated with adverse outcomes including spontaneous miscarriage, recurrent miscarriage, and preterm delivery.The objective of the study was to determine whether thyroid antibody positivity in the first trimester of pregnancy in euthyroid women was associated with maternal and neonatal adverse outcomes.The present trial is a component of a prospective trial published in 2010 that evaluated screening for thyroid disease during pregnancy and the impact of levothyroxine therapy in women who were thyroid peroxidase positive with a TSH above 2.5 mIU/liter. The present study compared 14 maternal and neonatal adverse outcomes in 245 women who were euthyroid (TSH < 2.5 mIU/liter) and thyroid peroxidase positive in the first trimester to 3348 women who were euthyroid and thyroid peroxidase negative in the first trimester.The study was conducted in southern Italy at the ambulatory clinics of two community hospitals.The study consisted of 3593 women.There was no intervention.The main outcome measures were 14 maternal and neonatal complications.The main result was an increase in very preterm delivery (<34 wk gestation at delivery) [4.5 vs. 1.8%; Ï(2)(df = 1) = 8.58; P = 0.003] and respiratory distress [3.3 vs. 1.2%; Ï(2)(df = 1) = 7.80; P = 0.005] in women who were thyroid antibody positive.The present study provides further evidence of an association between thyroid antibody positivity and very preterm delivery in euthyroid women. The association with respiratory distress should be considered preliminary and awaits further study.