Health & Environmental Research Online (HERO)


Print Feedback Export to File
9554247 
Journal Article 
synthesis of 2-substituted-1 H-benzo[d]imidazoles through oxidative cyclization of O-phenylenediamine and substituted aldehydes using dioxanedibromide 
Birajdar, SS; Hatnapure, GD; Keche, AP; Kamble, VM 
2014 
0 
Research Journal of Pharmaceutical, Biological and Chemical Sciences
ISSN: 0975-8585 
5 
1 
487-493 
English 
Benzimidazole ring is a useful synthon in medicinal chemistry and is a part of many biologically active compounds. This communication reports a mild and efficient approach for the synthesis of benzimidazole ring through oxidative cyclization of o-phenylenediamine and different aldehydes using dioxane dibromide, as a user-friendly reagent. This is a new, convenient and facile methodology for the synthesis of 2-substituted-1H-benzo[d]imidazoles. 
Aldehyde; Benzimidazole; Cyclization; Dioxane dibromide; O-Phenylenediamine