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5078926 
Journal Article 
Trifluoromethylation of -diazoesters and -diazoketones with fluoroform-derived CuCF3: synergistic effects of co-solvent and pyridine as a promoter 
Ma,; Tsui, GA 
2019 
6 
1 
27-31 
English 
WOS:000454251300002 
We herein describe a new protocol for copper-mediated trifluoromethylation of α-diazoesters and α-diazoketones, both using readily available fluoroform-derived CuCF3. The synergistic effect of using 1,4-dioxane as a co-solvent and pyridine as a promoter is revealed. Reaction conditions are mild and easy to handle, allowing the synthesis of a range of α-trifluoromethyl esters and ketones in one-step from α-diazo carbonyl compounds. The ultimate CF3 source is the inexpensive, nontoxic, industrial waste fluoroform. 
Chemistry--Organic Chemistry; Ketones; Solvents; Organic chemistry; Carbonyl compounds; Synergistic effect; Pyridines; Industrial wastes; Carbonyls; Chemical synthesis; Trifluoromethane