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9559472 
Journal Article 
A synthesis of new liquid electrodes for the determination of ibuprofen, based on a molecularly imprinted polymer 
Al-Nisani, MM; Al-Bayati, YK; Osman, ME 
2021 
International Journal of Drug Delivery Technology
ISSN: 0975-4415 
Dr. Yashwant Research Labs Pvt. Ltd. 
11 
2 
308-312 
English 
Liquid electrodes of Ibuprofen (IBP) imprinted polymer were synthesis based on precipitation polymerization mechanism. The molecularly imprinted (MIP) and non-imprinted (NIP) polymers were synthesized using IBP as a template. By 1-Vinylimidazole (VIZ) and Styrene as monomers, Ethylene glycol dimethyl acrylate (EGDMA) cross-linkers and benzoyl peroxide (BPO) as an initiator. The molecularly imprinted membranes were synthesis using Di-octyl phthalate(DOPH) Nitro benzene (NB), Di-butyl phthalate (DBPH), and Di-butyl Sebacate (DBS) plasticizers in PVC matrix. The slopes and limit of detection of liquid electrodes obtained from the calibration curves ranged from (30.5, 29.9) (19.003, 20.46) mV/decade and 1.2 x 10-7–2.3 x 10-8 and 7 × 10-7, 7.1 × 10-7 M, respectively and the response time was about 60 seconds. The liquid electrodes were filled with a typical 10-1 M drug solution and demonstrated a consistent response across a pH scale of 1 to 10, as well as good selectivity across a wide range of species. State-of-the-art electrodes have been successfully used to detect Ibp in pharmaceutical samples without any time-consuming pre-treatment steps. © 2021, Dr. Yashwant Research Labs Pvt. Ltd.. All rights reserved. 
(VIZ) monomers; Ibuprofen; Molecularly imprinted electrodes; Nitrobenzene; Potentiometric method; Styrene