Objective: To investigate the chemical constituents from Aganosma marginata and to provide the material basis for the quality control. Methods: The chemical constituents were separated and purified by silica gel Sephadex LH-20, MCI. Their structures were determined by physicochemical properties and spectral data analyses. Results: Twenty three compounds were isolated from A. marginata and identified as: periseoside C (1), 3-O-β-D-glucopyranosyl-3β,15α-dihydroxypregn-5-en-20-one (2), 3β,20α-dihydroxy- 5-en-pregane (3), 28-methylstigmast-5-en-3-ol (4), 29-norcycloart-23-ene-3,25-diol (5), 29-norcycloartan-3-ol (6), geniposidic acid (7), syringaresinol (8), syringaresinol-4,4'-O-bis-β-D-glucopyranoside (9), syringic acid 4-O-β-D-glucopyranoside (10), salicylic acid (11), scopoletin (12), azelaic acid (13), 3-O-[β-D-xylopyranosyl]-(1â4)-β-D-allopyranoside-14-hydroxycard-20 (22)-enolide (14), bis (2-ethylhexyl) phthalate (15), kaempferol-3-O-α-L-rhamnopyranosyl-(lâ4)-α-L-glucopyranoside (16), kaempferol-3-O-α-L- glucopyranoside-(1â2)-β-D-glucopyranoside (17), kaempferol-3-O-α-L-rhamnopyranosyl-(1â4)-[α-L-rhamnopyranosyl (1â4)]-β- D-glucopyranoside (18), kaempferol-3-O-α-L-rhamnopyranosyl-(1â4)-[β-D-glucopyranosyl-(1â4)]-β-D-glucopyranoside (19), hexacosanoicacid 1-carbonate (20), 5,8,12-trihydroxy-9-octadecenoic acid (21), (2S,3S,4R)-phytosphingosine (22), and nebularine (23). Conclusion: All the compounds are obtained from plants of Aganosma G. Don for the first time. © 2015, Editorial Office of Chinese Traditional and Herbal Drugs. All right reserved.
3-O-α-L-rhamnopyranosyl-(lâ4)-α-L-glucopyranoside; Aganosma marginata (Roxb.) G. Don; Geniposidic acid; Scopoletin; Syringaresinol; Syringaresinol-4,4'-O-bis-β-D-glucopyranoside; 28 methylstigmast 5 en 3 ol; 29 norcycloart 23 ene 3,25 diol; 29 norcycloartan 3 ol; 3 o (beta dextro xylopyranosyl) (1-4) beta dextro allopyranoside 14 hydroxycard 20 (22) enolide; 3 o beta dextro glucopyranosyl 3beta,15alpha dihydroxypregn 5 en 20 one; 3beta,20alpha dihydroxy 5 en pregane; 5,8,12 trihydroxy 9 octadecenoic acid; azelaic acid; geniposidic acid; hexacosanoicacid 1 carbonate; kaempferol 3 o alpha levo glucopyranoside (1-2) beta dextro glucopyranoside; kaempferol 3 o alpha levo rhamnopyranosyl (1-4) (alpha levo glucopyranosyl(1-4))beta dextro glucopyranoside; kaempferol 3 o alpha levo rhamnopyranosyl (1-4) (beta dextro glucopyranosyl(1-4))beta dextro glucopyranoside; kaempferol 3 o alpha levo rhamnopyranosyl (1-4) alpha levo glucopyranoside; nebularine; periseoside c; phthalic acid bis(2 ethylhexyl) ester; phytosphingosine; salicylic acid; scopoletin; sephadex; silica gel; syringaresinol; syringaresinol 4,4' o bis beta dextro glucopyranoside; syringic acid 4 o beta dextro glucopyranoside; unclassified drug; Aganosma marginata; Apocynaceae; Article; chemical composition; chemical structure; drug isolation; physical chemistry; purification; quality control; separation technique; spectroscopy