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9559898 
Journal Article 
Chemical composition of leaf essential oil of Synsepalum dulcificum and evaluation of its antibacterial and antitumoral activities in vitro 
Lu, SL; Liu, H; Chen, GY; Han, CR; Zang, WX 
2014 
0 
Chemistry and Industry of Forest Products
ISSN: 0253-2417 
Chemistry and Industry of Forest Products 
34 
1 
121-127 
English 
The aim of this study was to determine the chemical composition of Synsepalum dulcificum leaf essential oil obtained by steam distillation. The in vitro antibacterial activity and antitumoral activity of this essential oil was characterized. Sixty-eight compositions were separated. Among them 44 components were identified and represented 92.14% of the total detected constituents. The major chemical compounds of leaf essential oil were spathulenol (24.194%), limonene (15.805%), diisooctyl phthalate (12.402%), dibutyl phthalate (10.326%), palmitic acid (4.865%) and linalool (2.139%). The result of the antimicrobial assay showed that the essential oil displayed varying degrees of antibacterial activity against all tested bacterial except for Pseudomonas aeruginosa, along with minimum inhibition concentration(MIC) values from 39.06 to 252.15 mg/L. In addition, the antitumoral activity using MTT assay of the leaf essential oil exhibited this oil was effective against human K562 cancer cell line in a dose dependent manner. Its inhibition concentration 50% (IC50) value was 13.5 mg/L. 
Antibacterial activity; Antitumoral activity; Chemical composition; Essential oil; Synsepalum dulcificum leaf; Cell culture; Distillation; Esters; Anti-bacterial activity; Anti-tumoral activity; Chemical compositions; Dose-dependent manner; Inhibition concentrations; Minimum inhibition concentrations; Pseudomonas aeruginosa; Synsepalum dulcificum leaf; Essential oils