Health & Environmental Research Online (HERO)


Print Feedback Export to File
9663144 
Journal Article 
Influence of parameters in physiologically-based extraction test on the bioaccessibility of phthalate esters and phosphorus flame retardant in indoor dust 
Li, Y; He, R; Han, Y; Xiang, P; Luo, J; Cui, X 
2016 
Yes 
Huanjing Kexue Xuebao / Acta Scientiae Circumstantiae
ISSN: 0253-2468 
Science Press 
36 
5 
1841-1848 
Chinese 
Incidental ingestion of indoor dust is an important exposure pathway for phthalate esters (PAEs) and phosphorus flame retardants (PFRs). The bioaccessibility of these compounds in indoor dust is essential for the risk assessment. In the current study, bioaccessibility of dibutyl phthalate (DBP), butyl benzyl phthalate (BBP), di(2-ethylhexyl) phthalate (DEHP) and tris(2-chloroethyl) phosphate (TCEP) in indoor dust was measured by physiologically based extraction test (PBET). The influences of bile contents, intestinal solution pH, liquid-solid ratio, and the presence of milk powder on the bioaccessibility result were investigated. The bioaccessibility decreased with the increase of contaminant Kow with 52% for TCEP and 1.5% for DEHP. The bioaccessibility of DBP, BBP, and DEHP was positively related with bile contents, and became saturated when bile content was 10 g·L-1. No significant effect of bile was observed for TCEP due to its relatively higher solubility. The bioaccessibility significantly increased in the presence of milk powder, and became stable when milk powder reached about 10 g·L-1. Increasing liquid-to-solid ratio led to increased bioaccessibility of DBP and DEHP but slight change for BBP and TCEP. When pH changed from 6 to 8, there was no significant change for bioaccessibility of all four types of contaminants. © 2016, Science Press. All right reserved. 
Bioaccessibility; Indoor dust; Phosphorus flame retardants; Phthalate esters; Physiologically based extraction test; bioavailability; dust; extraction method; flame retardant; indoor air; phosphate; phthalate; physiological response; risk assessment