US EPA

971241 

Journal Article 

Review 

Uric acid as a pathogenic factor in preeclampsia 

Bainbridge, SA; Roberts, JM 

2008 

1 

Placenta
ISSN: 0143-4004
EISSN: 1532-3102 

29 Suppl A 

S67-S72 

English 

18093648 

10.1016/j.placenta.2007.11.001 

WOS:000254629200014 

Hyperuricemia is a common finding in preeclamptic pregnancies evident from early pregnancy. Despite the fact that elevated uric acid often pre-dates the onset of clinical manifestations of preeclampsia, hyperuricemia is usually considered secondary to altered kidney function. Increased serum uric acid is associated with hypertension, renal disease and adverse cardiovascular events in the non-pregnant population and with adverse fetal outcomes in hypertensive pregnancies. We hypothesize that an elevated concentration of uric acid in preeclamptic women is not simply a marker of disease severity but rather contributes directly to the pathogenesis of the disorder. Using epidemiological and experimental evidence, gained largely outside of pregnancy, we will propose pathogenic roles for uric acid in preeclamptic pregnancies. Uric acid's ability to promote inflammation, oxidative stress and endothelial dysfunction will be highlighted with discussions of the potential impact on placental development and function and maternal vascular health. 

preeclampsia; uric acid; pathophysiology; placenta; cardiovascular disease 

13th International-Federation-of-Placenta-Association Meeting 

AUG 17-22, 2007