US EPA

972424 

Journal Article 

A study on the mononuclear bivalent manganese and coer complexes of twelve membered hexaaza [N(6)] macrocyclic ligand: Synthesis, spectral and in vitro antifungal screening 

Kumar, U; Chandra, S 

2011 

Yes 

Journal of the Indian Chemical Society
ISSN: 0019-4522 

88 

5 

647-652 

English 

WOS:000292057300005 

New manganese(II) and copper(II) complexes of 12-membered macrocyclic Schiff base ligand containing thiosemicarbazone moiety have been prepared having general composition [MLX(2)] where M = Mn(II) or Cu(II), L = 3,4,9,10-tetra-2-furanyl-1,2,5,6,8,11-hexaazacyclododeca-7,12-dithione-2,4,8,10-tetraene and X = Cl(-), NO(3)(-) and NCS(-). The complexes have been characterized by elemental analysis, molar conductance, magnetic susceptibility measurements and spectral (IR, electronic, EPR and mass) techniques. The IR spectra of complexes suggested that ligand is coordinated to the metal ion through imine nitrogen atoms. On the basis of spectral studies, an octahedral and tetragonal geometry has been assigned for MO and CuIIcomplexes respectively. EPR spectra of polycrystalline Mn(II) complexes gave an isotropic signal with g value centered around free electron g value. EPR spectra of Mn(II) complexes in DMSO showed hyper-fine splitting containing six lines whereas EPR spectra of polycrystalline CuII complexes showed anisotropic signal. Conductivity measurements supported the non electrolytic nature of the complexes. Magnetic moment data suggested the paramagnetic and high spin nature of the complexes. All the complexes have also been tested in vitro against a number of pathogenic fungi. Results indicated that the complexes exhibited good antifungal activity. Thermal analysis of reported complexes suggested no weight loss up to 120-150 degrees C and indicated the absence of water molecule either in or outside the coordination sphere. 

Spectroscopic; macrocyclic; octahedral; antifungal; tetragonal; anisotropic