Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
9725360
Reference Type
Journal Article
Title
Prognostic parameters for recurrence of papillary thyroid microcarcinoma
Author(s)
Kim, TY; Hong, SJ; Kim, JM; Kim, WG; Gong, G; Ryu, JS; Kim, WB; Yun, SC; Shong, YK
Year
2008
Is Peer Reviewed?
Yes
Journal
BMC Cancer
ISSN:
1471-2407
EISSN:
14712407
Volume
8
Page Numbers
296
Language
English
PMID
18851763
DOI
10.1186/1471-2407-8-296
Abstract
BACKGROUND:
Papillary thyroid microcarcinoma (PTMC) is defined as a papillary thyroid carcinoma less than or equal to 1.0 cm in size. Independent prognostic factors for clinical recurrence of PTMC have not been clearly delineated.
METHODS:
Clinicopathological parameters predicting PTMC recurrence were determined by retrospective analysis of 307 patients.
RESULTS:
Of the 293 patients eligible for analysis, 14 (5%) had recurrence during a median follow-up time of 65 months. Recurrence was observed in 8 of 166 patients (0.5%) treated with total or near-total thyroidectomy; gender (P = 0.02) and presence of lateral cervical node metastases at initial surgery (P = 0.01) were associated with recurrence. Six of the 127 patients (0.5%) treated with hemi- or subtotal thyroidectomy experience recurrences, but no significant prognostic factor for recurrence was identified. Multivariate Cox-regression analysis showed that gender and cervical lymph node metastasis were significant variables
CONCLUSION:
PTMC showed very diverse disease extent and could not be regarded as indolent, relatively benign disease based on the primary tumor size. The extent of surgery should be based on prognostic parameters, such as gender and lateral neck node metastasis, in patients with PTMC.
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity