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HERO ID
981998
Reference Type
Journal Article
Title
Gastric ulcer healing activity of Sri Lankan black tea (Camellia sinensis L.) in rats
Author(s)
Ratnasooriya, WD; Fernando, TSP
Year
2009
Is Peer Reviewed?
1
Journal
Pharmacognosy Magazine
ISSN:
0973-1296
Volume
5
Issue
19
Page Numbers
260-265
Language
English
Web of Science Id
WOS:000270809600013
Abstract
This study examined the gastric ulcer healing potential of black tea (Camellia sinensis) using Sri Lankan high grown Dust grade No: 1 black tea in rat acetic acid-induced gastric ulcer model. Three oral doses (84, 167 or 501 mg/ml) of black tea brew (BTB) made according to ISO recommendations were used in the evaluation of gastric ulcer healing activity. The results showed a significant (P < 0.05) and dose-dependent gastric ulcer healing activity (in terms of reduction in gastric ulcer area). This effect had a rapid onset (with in 14 days). The gastric ulcer healing activity of BTB was however inferior (by 9 fold) to omeparazole, the reference drug. BTB displayed in vitro antioxidant activity (using DPPH assay; by 2985-3923 Trolox equivalents mu g/l), and also inhibited in vitro nitric oxide production (3-78 %). In addition, BTB had antihistamine activity (by wheal test; by 33.5%) and increased the gastric pH (from 3.3 to 5.9) and impaired the gastric acid output (by 69%). It is concluded that black tea possessed strong, oral gastric ulcer healing activity which is mediated via multiple mechanisms.
Keywords
Black tea; Camellia sinensis; Gastric ulcer healing
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