Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
9919768
Reference Type
Journal Article
Title
The exchange of thyroxine between plasma and liver: the role of free thyroxine
Author(s)
Hillier, AP
Year
1975
Is Peer Reviewed?
1
Journal
Acta Endocrinologica
ISSN:
0001-5598
Volume
78
Issue
2
Page Numbers
270-275
Language
English
PMID
803749
DOI
10.1530/acta.0.0780270
Abstract
An investigation has been made into the exchange of thyroxine between human plasma and the perfused rat liver. A stop-flow method was used to hold plasma within the liver sinusoids for periods up to 20 min. At 20 degrees C it was found that thyroxine present in the sinusoids transferred to the liver at a rate of 5-6%/min; and that thyroxine transferred from the liver to the plasma at a rate of 1%/min. In a second series of experiments, trace amounts of free thyroxine were injected into the stream of plasma just as it entered the tissue; the liver captured 18.5% of this injected hormone. In the discussion it is noted that 29% of the plasma thyroxine dissociates into free solution each minute. If the liver is able to capture 18.5% of this hormone (as the above experiment suggests) then the plasma-to-liver transfer rate would be 5-6%/min, which is the rate actually observed. These observations strongly suggest that the transfer of thyroxine from plasma to liver involves its initial release into the free state followed by trapping by the tissue binding sites.
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity