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9928654 
Journal Article 
Effects of vitamin B12 on bright light on cognitive and sleep-wake rhythm in Alzheimer-type dementia 
Ito, T; Yamadera, H; Ito, R; Suzuki, H; Asayama, K; Endo, S 
2001 
1 
Psychiatry and Clinical Neurosciences
ISSN: 1323-1316
EISSN: 1440-1819 
55 
3 
281-282 
English 
11422876 
The present study investigated the effects of vitamin B12 (VB12) on circadian rhythm in Alzheimer-type dementia (ATD). Twenty-eight ATD patients were treated with bright light therapy (BLT) for 8 weeks. For the latter 4 weeks, half were treated with VB12 with BLT (BLT + VB12). We evaluated the cognitive state with Mini-Mental State Examination and the circadian rhythm with actigraphy after the fourth and eighth week. After the first 4 weeks BLT improved the circadian rhythm disturbances and cognitive state especially in the early stage of ATD. Although the latter 4 week-BLT caused no significant effects on the circadian rhythm; BLT + VB12 improved the vigilance level during the daytime. These results suggest that VB12 has some efficiency to enhance vigilance for ATD patients.