Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
9936165
Reference Type
Journal Article
Title
No survival difference after successful (131)I ablation between patients with initially low-risk and high-risk differentiated thyroid cancer
Author(s)
Verburg, FA; Stokkel, MP; Düren, C; Verkooijen, RB; Mäder, U; van Isselt, JW; Marlowe, RJ; Smit, JW; Reiners, C; Luster, M
Year
2010
Is Peer Reviewed?
Yes
Journal
European Journal of Nuclear Medicine and Molecular Imaging
ISSN:
1619-7070
EISSN:
1619-7089
Volume
37
Issue
2
Page Numbers
276-283
Language
English
PMID
20091165
DOI
10.1007/s00259-009-1315-6
Abstract
PURPOSE:
To compare disease-specific survival and recurrence-free survival (RFS) after successful (131)I ablation in patients with differentiated thyroid carcinoma (DTC) between those defined before ablation as low-risk and those defined as high-risk according to the European Thyroid Association 2006 consensus statement.
METHODS:
Retrospective data from three university hospitals were pooled. Of 2009 consecutive patients receiving ablation, 509 were identified as successfully ablated based on both undetectable stimulated serum thyroglobulin in the absence of antithyroglobulin antibodies and a negative diagnostic whole-body scan in a follow-up examination conducted 8.1+/-4.6 months after ablation. Of these 509 patients, 169 were defined as high-risk.
RESULTS:
After a mean follow-up of 81+/-64 months (range 4-306 months), only three patients had died of DTC, rendering assessment of disease-specific survival differences impossible. Of the 509 patients, 12 (2.4%) developed a recurrence a mean 35 months (range 12-59 months) after ablation. RFS for the duration of follow-up was 96.6% according to the Kaplan-Meier method. RFS did not differ between high-risk and low-risk patients (p=0.68). RFS differed slightly but significantly between those with papillary and those with follicular thyroid carcinoma (p=0.03) and between those aged =45 years those aged >45 years at diagnosis (p=0.018).
CONCLUSION:
After (near) total thyroidectomy and successful (131)I ablation, RFS does not differ between patients classified as high-risk and those classified as low-risk based on TNM stage at diagnosis. Consequently, the follow-up protocol should be determined on the basis of the result of initial treatment rather than on the initial tumour classification.
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity