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10176840 
Journal Article 
Specificity of the toxic genetic action of carcinogenic aromatic compounds on mus-mutant strains of Drosophila 
Shpigel'man VS; Fuks, SY; Safaev, RD; Belitskiĭ, GA 
1991 
Yes 
Bulletin of Experimental Biology and Medicine
ISSN: 0007-4888
EISSN: 1573-8221 
112 
11 
1631-1633 
English 
WOS:A1991HQ08700031 
is translation of 2148678 [The specificity of the genotoxic action of carcinogenic aromatic compounds on Drosophila mus mutants]
Genetic toxic effects of chemical carcinogens are revealed in Drosophila in the form of mutations in sex or somatic cells [1] or as their lethal action on larvae. The toxic effect increases to the level of hypersentivity in specially created mutant strains, defective for DNA repair [7]. Among these strains, the mus-mutants of Drosophila melanogaster obtained by Henderson and co-workers, and characterized by sensitivity to several direct and indirect action carcinogens [5], are of great interest. Since precarcinogens are activated to genetic toxic metabolites by microsomai monooxygenases [6], it was important to discover if correlation exists between the sensitivity of individual strains to precarcinogens and the activity of these enzymes in them. To use mus-mutants as the test object for screening carcinogens, it is also necessary to know how specific their sensitivity to these agents may be, i.e., to study their effects parallel with the action of noncarcinogenic analogs. 
Drosophila; genetic toxicity; specificity; metabolism; precarcinogens