[The specificity of the genotoxic action of carcinogenic aromatic compounds on Drosophila mus mutants] | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

2148678

Reference Type

Journal Article

Title

[The specificity of the genotoxic action of carcinogenic aromatic compounds on Drosophila mus mutants]

Author(s)

Shpigel'man VS; Fuks, S; Safaev, RD; Belitskiĭ, GA

Year

1991

Is Peer Reviewed?

Yes

Journal

Byulleten' Eksperimental'noi Biologii i Meditsiny
ISSN: 0365-9615

Volume

112

Issue

Page Numbers

521-523

Language

Russian

PMID

1810494

Web of Science Id

BCI:BCI199294041637

Relationship(s)

has translation 10176840 Specificity of the toxic genetic action of carcinogenic aromatic compounds on mus-mutant strains of Drosophila

Abstract

Hypersensitivity to the toxic effect of benzo(a)pyrene (B(a)P) was determined in homozygous larvae of two D. melanogaster mus strains (mus 208B2 and mus210). The two others (mus205B1 and mus208B1) were found to be less sensitive and the parent strain was resistant. The lack of correlation between the sensitivity in larvae and the activity of aryl hydrocarbon hydroxylase in S15 fractions from adult flies whole body homogenates of the same strains was demonstrated. The hypertoxic effect of B(a)P and 2-acethylaminofluorene in strain mus210 seems to be rather specific because noncarcinogenic pyrene, benzo(e)pyrene and fluorene did not affect the survival of this most sensitive strain. Perspectives of the strain mus210 use for the environmental genotoxic pollutants screening were discussed.