US EPA

1037406 

Journal Article 

Study on the diuretic activity of Strychnos potatorum Linn. seed extract in albino rats 

Biswas, S; Murugesan, T; Maiti, K; Ghosh, L; Pal, M; Saha, BP 

2001 

1 

Phytomedicine
ISSN: 0944-7113
EISSN: 1618-095X 

8 

6 

469-471 

English 

11824523 

WOS:000173677900009 

Methanol extract of Strychnos potatorum Linn. seeds (SPSE) was evaluated for its diuretic activity in Wistar albino rats. The SPSE was administered at the graded doses of 200, 400, and 600 mg/kg body weight. The parameters which were taken into account during the experimental on each rat were: total urine volume (corrected for water intake during the test period), body weight before and after the experiment, and the concentration of sodium, potassium, and chloride ions in urine. The total urine volumes of the SPSE (600 mg/kg)-treated rats were evaluated nearly two and half fold then compared with the control (saline treated) group. Excretion of cations (sodium and potassium ions) and anions (chloride ions) also increased significantly with respect to the control group. The diuretic effect was comparable with that of the standard drug Furosemide. The increase of cations in the urine on treatment with Strychnospotatorum seed extract (SPSE) was dose-dependent. This effect supports the use of the Strychnos potatorum seeds as a diuretic in folk remedies. 

SPSE; Strychnos potatorian; diuretic