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1037984 
Journal Article 
New synthesis of (RS)-carnitine chloride 
Boots, SG; Boots, MR 
1975 
Yes 
Journal of Pharmaceutical Sciences
ISSN: 0022-3549
EISSN: 1520-6017 
64 
7 
1262-1264 
English 
1151695 
A four-step synthesis of (RS)-carnitine chloride was developed using extremely mild reaction conditions and versatile intermediates. Crotyl chloride was converted to tert-butyl 3-butenoate using tert-butyl alcohol and triethylamine in ether. Treatment of tert-butyl 3-butenoate with m-chloroperbenzoic acid in chloroform afforded tert-butyl 3,4-epoxybutyrate. Reaction of this compound with trimethylamine hydrochloride in methanol, followed by mild acid hydrolysis of the tert-butyl ester, afforded (RS)-carnitine chloride. 
IRIS
• tert-Butanol
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