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1041802 
Journal Article 
The McLafferty rearrangement in the Glu residue in a cyclic lipopeptide determined by Q-TOF MS/MS 
Yang, SZ; Liu, XY; Mu, BZ 
2008 
Yes 
Journal of Mass Spectrometry
ISSN: 1076-5174
EISSN: 1096-9888 
43 
12 
1673-1678 
English 
18613277 
WOS:000261811800009 
The intraresidue rearrangement and loss of the side chain of the Glu residue was found through MS/MS analysis of both original and methanol-esterified lipopeptides. Both Glu and Asp residues in the cyclic lipopeptide were esterified. The MS/MS results showed that the loss of fragment 72 or 86 was induced by McLafferty-type rearrangement from the Glu or esterified Glu. The mechanism of loss of the Glu residue can be used to determine or to corroborate the existence of the Glu and to help understand the fragment formation in MS/MS. The cleavage mechanism and m/z intensities imply that the sodium ion was easier attached and the cleavage would easily occur at specific sites. 
amino acid residue; Glu; MS/MS; cyclic lipopeptide; methanol-esterified; McLafferty rearrangement 
IRIS
• Methanol (Non-Cancer)
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