Sodium tetramethoxyborate: an efficient catalyst for Michael additions of stabilized carbon nucleophiles | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

1042582

Reference Type

Journal Article

Title

Sodium tetramethoxyborate: an efficient catalyst for Michael additions of stabilized carbon nucleophiles

Author(s)

Campaña, AG; Fuentes, N; Gómez-Bengoa, E; Mateo, C; Oltra, JE; Echavarren, AM; Cuerva, JM

Year

2007

Is Peer Reviewed?

Yes

Journal

Journal of Organic Chemistry
ISSN: 0022-3263
EISSN: 1520-6904

Volume

Issue

Page Numbers

8127-8130

Language

English

PMID

17880141

DOI

10.1021/jo701354c

Web of Science Id

WOS:000249986500045

Abstract

Sodium tetramethoxyborate, easily prepared by reaction of inexpensive sodium borohydride with methanol, possesses a suitable combination of a Lewis base and a Lewis acid to catalyze Michael reactions at room temperature under practically neutral conditions. This reaction provides good to excellent yields of Michael addition products from a broad scope of Michael donor and Michael acceptor reagents.