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HERO ID
10494782
Reference Type
Journal Article
Title
Comparative effects of vitamin K and vitamin D supplementation on calcium balance in young rats fed normal or low calcium diets
Author(s)
Iwamoto, J; Yeh, JK; Takeda, T; Sato, Y
Year
2005
Is Peer Reviewed?
Yes
Journal
Journal of Nutritional Science and Vitaminology
ISSN:
0301-4800
Volume
51
Issue
4
Page Numbers
211-215
Language
English
PMID
16261991
DOI
10.3177/jnsv.51.211
Web of Science Id
WOS:000231568700001
Relationship(s)
has retraction
5040664
Retraction
Abstract
We examined the effect of vitamin K and vitamin D supplementation on calcium balance in young rats fed a normal or low calcium diet. Eighty female Sprague-Dawley rats, 6 wk of age, were randomized by the stratified weight method into eight groups with 10 rats in each group: 0.5% (normal) or 0.1% (low) calcium diet, 0.5% or 0.1% calcium diet+vitamin K (vitamin K2, menatetrenone, 30 mg/100 g, food intake), 0.5% or 0.1% calcium diet+vitamin D (25 microg/100 g, food intake), and 0.5% or 0.1% calcium diet+vitamin K+vitamin D. The duration of the study was 10 wk. Vitamin K supplementation promoted the reduction in urinary calcium excretion and retarded the abnormal elevation of serum PTH level in rats fed a low calcium diet, and stimulated intestinal calcium absorption in rats fed a normal calcium diet. Vitamin D supplementation stimulated intestinal calcium absorption with prevention of the abnormal elevation of serum PTH levels and prevented hypocalcemia in rats fed a low calcium diet, and stimulated intestinal calcium absorption in rats fed a normal calcium diet. The stimulation of intestinal calcium absorption was associated with increased serum 1,25-dihydroxyvitamin D levels. An additive effect of vitamin K and vitamin D on intestinal calcium absorption was found only in rats fed a normal calcium diet. This study shows the differential effects of vitamin K and vitamin D supplementation on calcium balance in young rats fed a normal or low calcium diet.
Keywords
vitamin K; vitamin D; intestinal calcium absorption; urinary calcium excretion
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