Ionic equilibria in neutral amphiprotic solvents: Structural effects on dissociation constants of several substituted phenols and mercaptopyrimidines in isopropyl alcohol | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

1071598

Reference Type

Journal Article

Title

Ionic equilibria in neutral amphiprotic solvents: Structural effects on dissociation constants of several substituted phenols and mercaptopyrimidines in isopropyl alcohol

Author(s)

Bosch, E; Ràfols, C; Rosés, M

Year

1989

Is Peer Reviewed?

Journal

Talanta
ISSN: 0039-9140
EISSN: 1873-3573

Volume

Issue

Page Numbers

1227-1231

Language

English

PMID

18964895

Web of Science Id

WOS:A1989CJ46500010

Abstract

The dissociation constants of several families of acids (substituted phenols and mercaptopyrimidines) in isopropyl alcohol medium have been determined by potentiometric titration with tetrabutylammonium hydroxide. Because of ion-pair formation the incomplete dissociation of the tetrabutylammonium salt has been taken into account in the calculation of pK(a). The dissociation constants of the salts were previously measured conductometrically. The resolution of acid strength in isopropyl alcohol relative to that in water has been determined for each series of acids by plotting the pK(a) values in isopropyl alcohol vs. those in water. The results show greater resolution in isopropyl alcohol than in water. The resolution of acid strength in tert-butyl alcohol relative to that in isopropyl alcohol has also been determined.