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HERO ID
1081316
Reference Type
Journal Article
Title
A computer model for the simulation of fiber-cell interaction in the alveolar region of the respiratory tract
Author(s)
Sturm, R
Year
2011
Is Peer Reviewed?
Yes
Journal
Computers in Biology and Medicine
ISSN:
0010-4825
Volume
41
Issue
7
Page Numbers
565-573
Language
English
PMID
21632043
DOI
10.1016/j.compbiomed.2011.05.009
Web of Science Id
WOS:000292950300016
Abstract
A mathematical model is presented that describes the health-endangering interaction of fibrous particles deposited in the human alveoli with alveolar fluids, cells, and tissues. As suggested by the theoretical approach, short fibers (diameter: 0.5 μm, length: 2-10 μm) are preferably ingested by alveolar macrophages and removed from the alveolar surface 10-15 days after exposure. Long (diameter: 0.5 μm, length: 10-50 μm) biopersistent fibers are not effectively cleared from the alveoli due to the repeated process of frustrated phagocytosis. Long biosoluble fibers also undergo a frustrated phagocytosis, with processes of extensive lysis leading to their significant shortening. The decrease in length causes the initiation of those clearance mechanisms that are efficient for short fibers.
Keywords
Compartment model; Fiber; Alveolar macrophages; Interstitium; Lung cancer
Tags
IRIS
•
Asbestos
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Libby Amphibole Asbestos (Draft, 2011)
OPPT REs
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OPPT_Asbestos, Part I: Chrysotile_C. Engineering
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OPPT_Asbestos, Part I: Chrysotile_D. Exposure
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OPPT_Asbestos, Part I: Chrysotile_E. Fate
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OPPT_Asbestos, Part I: Chrysotile_F. Human Health
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OPPT_Asbestos, Part I: Chrysotile_Supplemental Search
LitSearch: Sept 2020 (Undated)
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