US EPA

1109193 

Journal Article 

Constituents and antiproliferative activity of extracts from leaves of Croton macrobothrys 

Motta, LB; Furlan, CM; Santos, DYAC; Salatino, MLF; Duarte-Almeida, JM; Negri, G; de Carvalho, JE; Ruiz, ALTG; Cordeiro, I; Salatino, A 

2011 

0 

Revista Brasileira de Farmacognosia
ISSN: 0102-695X 

Sociedade Brasileira de Farmacognosia 

21 

6 

972-977 

English 

10.1590/S0102-695X2011005000174 

WOS:000297216900006 

Croton macrobothrys Baill, Euphorbiaceae, is a tree from the Atlantic Forest in Southern Brazil, used in traditional medicine and popularly known as dragon's blood and "pau-sangue". Leaf n-hexane, dichloromethane and methanol extracts were analyzed by GC/MS and evaluated for their in vitro antiproliferative activity on cell lines 786-0 (kidney), HT-29 (colon), K562 (leukemia), NCI-ADR/ RES (drug resistant ovary), NCI-H460 (lung), MCF-7 (mammary), PC-3 (prostate), OVCAR-3 (ovary), U251 (glioma) and UACC-62 (melanoma). The dicloromethane extract exhibited activity against all cell lines at the concentration 25 μg/mL, in particular on cell lines NCI-H460 (GI50 0.33 μg/mL) and K5662 (GI50 0.91 μg/ mL). Relevant constituents in dichloromethane extract are the alkaloids corydine and salutaridine, as well as the diterpenes geranylgeraniol and crotonin-derived clerodanes. 

alkaloids; antiproliferative activity diterpenes; medicinal plants