Health & Environmental Research Online (HERO)


Print Feedback Export to File
1115863 
Journal Article 
Neuronal cell protective and antioxidant effects of phenolics obtained from Zanthoxylum piperitum leaf using in vitro model system 
Jeong, CH; Kwak, JH; Kim, JH; Choi, GN; Kim, DO; Heo, HJ 
2011 
Yes 
Food Chemistry
ISSN: 0308-8146
EISSN: 1873-7072 
125 
2 
417-422 
WOS:000284975200018 
In order to obtain basic data for the utilisation of Zanthoxylum piperitum leaf as a functional substance in the food industry, the antioxidative and neuronal cell protective effects of silica-gel open column chromatographic fractions, obtained from Z. piperitum leaf, were examined. ABTS and FRAP assays indicated that the ZP4 fraction (eluted with methanol/chloroform, 1:4, v/v) of Z. piperitum leaf was a more potent radical-scavenger and reducing agent than the other five fractions. The ZP4 fraction also presented protective effects against H(2)O(2)-induced neurotoxicity in a dose-dependent manner. Therefore, our study verified that the ZP4 fraction has strong antioxidative and neuronal protective effects which are correlated with its high level of phenolics, particularly quercitrin, afzelin, and hyperoside. These phenolics of Z. piperitum leaf can be utilised as effective and safe functional food substances, i.e., natural antioxidants, and may reduce the risk of neurodegenerative disorders. (C) 2010 Elsevier Ltd All rights reserved. 
Zanthoxylum piperitum; Quercitrin; Afzelin; Hyperoside; Antioxidant; Neuro-protective effect 
IRIS
• Methanol (Non-Cancer)
     Search 2012
          WOS