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Citation
Tags
HERO ID
1127
Reference Type
Journal Article
Subtype
Review
Title
Synopsis of the in vivo results obtained with the 10 known or suspected aneugens tested in the CEC collaborative study
Author(s)
Adler, ID
Year
1993
Is Peer Reviewed?
1
Journal
Mutation Research: Fundamental and Molecular Mechanisms of Mutagenesis
ISSN:
0027-5107
EISSN:
1873-135X
Volume
287
Issue
1
Page Numbers
131-137
Language
English
PMID
7683379
DOI
10.1016/0027-5107(93)90152-6
URL
http://linkinghub.elsevier.com/retrieve/pii/0027510793901526
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Abstract
The synopsis of the in vivo test results in the first collaborative CEC Aneuploidy Project with 10 selected chemicals, colchicine (COL), econazole (EZ), chloral hydrate (CH), hydroquinone (HQ), diazepam (DZ), thiabendazole (TB), cadmium chloride (CD), thimerosal (TM), pyrimethamine (PY) and vinblastine (VBL), allowed several conclusions. (1) The spindle poisons, COL and VBL, were positive in all bone marrow and germ cell tests; (2) the clastogen HQ also induced aneuploidy in somatic and germinal cells; (3) the other seven compounds gave contradictory results either between laboratories or between test systems which require further experimental clarification; (4) CREST labeling or in situ hybridization for centromere identification showed about 70% fluorescent signals in micronuclei induced by COL or VBL but only about 15% in HQ induced micronuclei; (5) the tests for induction of a delay in cell division progression can be recommended as a prescreen for possible aneugens; (6) all test methods applied in these experiments require standardization with respect to sample size, sampling times and statistical treatment of the data. A second CEC Aneuploidy Programme has started recently to answer some of the questions raised by the first study regarding tissue and sex specificities.
Tags
•
Trichloroethylene (TCE) (Final, 2011)
All References
Hazard
Genotox
OPPT REs
•
OPPT_Trichloroethylene (TCE)_C. Engineering
Total – title/abstract screening
Off topic
•
OPPT_Trichloroethylene (TCE)_D. Exposure
Total – title/abstract screening
Off topic
•
OPPT_Trichloroethylene (TCE)_E. Fate
Total – title/abstract screening
Off topic
•
OPPT_Trichloroethylene (TCE)_F. Human Health
Total – title/abstract screening
Off topic
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