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1144951 
Technical Report 
Reaction of sulfonylureas with methanol 
Chubb, FL; Simmons, DL 
1972 
IPA/72/62007 
J 
REF 4 
IPA COPYRIGHT: ASHP The hypoglycemic sulfonylureas tolbutamide, chlorpropamide and glyburide (glibornuride) react with refluxing methanol to form the amine salts of the corresponding methyl sulfonylcarbamates. The compounds were characterized and their structures proved by synthesis. 
Tolbutamide; reactions; with methanol; Chlorpropamide; Glibornuride; Antidiabetic agents; refluxing with methanol to form amine salt of corresponding methyl sulfonylcarbamate; tolbutamide(Antidiabetic agents; chlorpropamide(Antidiabetic agents; glibornuride(Antidiabetic agents; Sulfonylureas; Methanol; refluxing to form amine salt of corresponding methyl sulfonylcarbamate; Glyburide 
IRIS
• Methanol (Non-Cancer)
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